Phase III Soft Tissue Sarcoma Trials: Success or Failure?
نویسندگان
چکیده
منابع مشابه
Phase III Soft Tissue Sarcoma Trials: Success or Failure?
OPINION STATEMENT Two recently reported phase III randomised control trials (RCTs) have resulted in the registration of two new systemic therapies for advanced soft tissue sarcoma. Both of these trials' designs were informed by phase II data that guided the selection of sensitive STS diagnoses, enabling the demonstration of benefit in certain subtypes. A number of other phase III trials reporte...
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The successful conclusion of the Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) trial of drotrecogin alfa (activated) — the official generic nomenclature for recombinant human Activated Protein C — in severe sepsis represents a long awaited milestone in clinical sepsis research [1]. This multinational Phase III trial successfully achieved a statistically s...
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BACKGROUND The EORTC-STBSG coordinated two large trials of adjuvant chemotherapy (CT) in localized high-grade soft tissue sarcoma (STS). Both studies failed to demonstrate any benefit on overall survival (OS). The aim of the analysis of these two trials was to identify subgroups of patients who may benefit from adjuvant CT. PATIENTS AND METHODS Individual patient data from two EORTC trials co...
متن کاملSoft tissue sarcoma.
Soft tissue sarcomas are rare tumours of the connective tissue. The knowledge of this rare entity is necessary for an accurate diagnosis. The incidence in Europe is about 3,6/100 000 per year. The first line treatment consists of a wide resection of the tumour, possibly combined with an adjuvant radiation therapy. A chemotherapy can be indicated and has to be evaluated for each case individuall...
متن کاملSoft-tissue sarcoma.
Soft-tissue sarcomas are rare malignancies of mesodermal origin. Common sites of involvement include the extremities, trunk, retroperitoneum, and the head and neck. Soft-tissue sarcomas of the extremities and pelvis are the most relevant to the orthopaedic surgeon. The patient with extremity soft-tissue sarcoma typically presents with a painless, enlarging mass. Advanced imaging techniques and ...
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ژورنال
عنوان ژورنال: Current Treatment Options in Oncology
سال: 2017
ISSN: 1527-2729,1534-6277
DOI: 10.1007/s11864-017-0457-1